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Jacob Siedlik 211

Dr. Jacob Siedlik

Biography

Dr. Jake Siedlik is an Associate Professor in the Department of Biology, specializing in computational biology. From a computational perspective, Dr. Siedlik has focused on ways to leverage data in conjunction with advanced statistical methodologies to answer fundamental biological and physiological questions while advancing the use of computational technologies in biomedical research. This work has centered on multiomic approaches to data analysis that include metabolomic, lipidomic, and proteomic pipelines. The use of varied statistical methods has allowed Dr. Siedlik to work within a variety of areas, including investigating how certain supplements alter performance in elite athletes, examining the effect of resistance training paired with creatine supplementation in rodent models undergoing chemotherapy, and quantifying how high-intensity, dual stress challenges impact ethical decision making in United States Marines.

Dr. Siedlik earned his B.A. in mathematics from Colorado College, his M.A. in applied physiology from Teachers College at Columbia University, and his Ph.D. in exercise physiology from the University of Kansas. Before his graduate studies, Siedlik was a police officer and sergeant with the New York City Police Department.

Degrees & Institutions

  • Ph.D Exercise Physiology, University of Kansas
  • M.A. Applied Physiology, Teachers College, Columbia University
  • B.A. Mathematics, Colorado College  

Research

The major goal of my laboratory has been the development of statistical models to best approximate in vivo immune responses in human subjects. The human immune response is highly variable and greater efforts are required to understand the variance in those responses to realize potential health benefits. A large part of this work revolves around the use of Bayesian statistics to better quantify variability around specific metrics. The hope is that the Bayesian approach will improve decision making capabilities for scientists and clinicians working with human subjects.

Current Courses

  • Biology I Lab

Special Interests

Dr. Siedlik enjoys running and water activities when not working in the classroom or lab.

Publications

  1. Doll, A. Anzalone, M. Clarke, K. Cooper, A. Polich, and J. Siedlik. A call for a health data-informed workforce among clinicians. JMIR Medical Education, 2024, (In press).
  2. Gonzalez, C. Jachino, B. Murphy, K. Heinemann, M. Magrini, E. Bredahl, J. Eckerson, and J. Siedlik. The effect of acute ketone supplementation on time to fatigue in NCAA Division I cross-country athletes. Nutraceuticals, 2024, Vol. 4(2), 232-240
  3. Magrini, R. Hoffman, T. Barnett, J. Bruursema, and J. Siedlik. Effectiveness of a multicomponent rehabilitation protocol on outcomes following post-acute care. Clin Biomech, 2024, 111:106138. doi: 10.1016/j.clinbiomech.2023.106138.
  4. Kelly, D. Emerson, B. McDermott, W. Atkins, C. Butts, R. Laursen, C. Troyanos, A. Duckett, and J. Siedlik. Gastrointestinal cell injury and perceived symptoms after running the Boston Marathon. Front Physiol, 2023, Vol.14, 1268306; https://doi.org/10.3389/fphys.2023.1268306
  5. Law, M. Magrini, J. Siedlik, J. Eckerson, K. Drescher, and E. Bredahl. Creatine and resistance training: A combined approach to attenuate doxorubicin-induced cardiotoxicity. Nutrients, 2023, Vol.15(18), 4048; https://doi.org/10.3390/nu15184048
  6. Graham, J. Siedlik, C. Toro, L. Harlow, and C. Cardozo. Boldine alters serum lipidomics signatures after acute spinal cord transection in male mice. Int J Envrion Res Public Health, 2023, Vol.20(16), 6591; https://doi.org/10.3390/ijerph20166591.
  7. E. Sheppard, L. Bryant, R.N. Wickramasekara, C. Vaccaro, [and 120 others, including J. Siedlik]. Mechanism of KMT5B haploinsufficiency in neurodevelopment in humans and mice. Science Advances, 2023, Vol.9(10).
  8. Pearson, N. Moodie, K. Stout, W. Hawkins, M. Matuszek, Z. Graham, J. Siedlik, J. Vardiman, and P. Gallagher. Similar responses in the Akt/Protein Kinase B signaling pathway following different lower-body exercise volumes in recreationally active men. JSCR, 2023, Vol.37(5), p. 1034 - 1041.
  9. L. Barker, J. Siedlik, M. Magrini, S. Uesato, H. Wang, A. Sjovold, G. Ewing, and J. Harry. Eccentric force-velocity profiling: Motor control strategy considerations and relationships to strength and jump performance. JSCR, 2023, Vol.37(3), p. 574-580.