Argo Journals Article

Volume 2010

Published on:
May 03, 2010

Award/Sponsor Info:
Chemistry Departmental Award


Synthesis and Biotransformation of Formestane

Author(s): Scott Shaw , Anne Marti , Glenroy Martin

Formestane is a biologically active steroid in the class of aromatase inhibitors. It is used in the treatment of breast cancer and ovarian cancer in postmenopausal woman. It suppresses the production of estrogen by inhibiting the aromatase enzyme which converts androgens into estrogens. In an attempt to increase its bioavailability the synthesis of formestane from testosterone was attempted. The structures of the steroid intermediates were determined by chemical and spectroscopic means.

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